Assistant Professor Biochemistry Medical Education 142/2018, 143/18, 144/18, 145/18 Answer Key

Post: Assistant Professor Biochemistry
Department: Medical Education
Category Code: 142/2018, 143/2018, 144/2018, 145/2018
Qualifications: MD (Biochemistry)/ DNB (Biochemistry) + Three year teaching experience
Date of Test: 23-05-2019


If you find mistakes, comment below

1. Dr. Gundert is associated with which of the following?
   • London Mission Society
   • Basel Evangelical Mission
   • Church Mission Society
   • Prussian Missionary
   
   
2. Who is the first editor of Swadesabhimani started by Vakkom Moulavi?
   • K.Ramakrishnapillai
   • C. Krishnapillai
   • C.P. Govindapillai
   • S. Padmanabha Panicker
   
   
3. In which conference did Sree Narayana Guru give the slogan "Not to argue and win but to know and make known"?
   • All Kerala Fraternity Conference at Aluva, 1921
   • All Kerala Industrial Conference at Cannanore, 1909
   • Superstition Eradication Conference at Kollam
   • All Religious Conference at Aluva, 1924
   
   
4. Mokshapradipam is a work written by
   • Vagbhadananda
   • Kumaran Asan
   • Brahmananda Sivayogi
   • Sankaracharya
   
   
5. Name the great social reformer who is said to have inspired the Shanar agitation for social equality?
   • Vaikunda Swamikal
   • E.V. Ramaswami Naicker
   • Poikayil Yohannan
   • Thaikkattu Ayyavu
   
   
6. When was the Malayali Memorial submitted to the Travancore Maharaja?
   • 11 January 1891
   • 1 January 1891
   • 1 September 1891
   • 11 September 1891
   
   
7. Aphante Makal is a novel written by
   • V.T. Bhattathiripad
   • Lalithambika Antarjanam
   • Bhavatratan Namboothiripadu
   • Karur Nilakantapillai
   
   
8. The leader of the Akalis who led the Sikhs in the Vaikom Satyagraha?
   • Gur Charan Singh
   • Lala Lal Singh
   • Lala Jai Singh
   • Mr. Amar Singh
   
   
9. Karmavipakom is the autobiography of
   • Karoor Nilakantan Namboothiripad
   • V.T. Bhattathiripad
   • M.C. Joseph
   • Sahodaran Ayyappan
   
   
10. The only Christian Satyagrahi who participated in the Vaikom Satyagraha and who was asked to quit the movement by Mahatma Gandhi?
    • Barister George Joseph
    • M.O. Mathai
    • Kandathil Varghese Mappilai
    • Joseph Pulikkunnel
    
    
11. Mitavadi was started by
    • C. Krishnan
    • C. Kesavan
    • Kunhiraman Nair
    • T. Sivasankaran
    
    
12. Who is known as 'Kesari'?
    • C.V. Kunhiraman Nair
    • E.M. Kovur
    • M.R. Nair
    • Vengayil Kunhiraman Nair
    
    
13. Who founded Malabar Economic Union?
    • T.K. Madhavan
    • Dr. P. Palpu
    • Moorkkothu Kumaran
    • Sahodaran Ayyappan
    
    
14. Jeevithasamaram is the autobiography of
    • A.K. Gopalan
    • C. Kesavan
    • E.M.S. Namboodiripad
    • K. Kelappan
    
    
15. Pattabakki is a drama written by
    • P. Krishnapillai
    • Kesava Dev
    • Thakazhi
    • K. Damodaran
    
    
16. Who is the founder of SEWA?
    • Swarnakumari Devi
    • Ramabhai Saraswathi
    • Ela Bhatt
    • Devi Chaudhurani
    
    
17. Protection of Women from Domestic Violence Act was passed in the year?
    • 2005
    • 2006
    • 2011
    • 2012
    
    
18. ILO is situated at
    • Rome
    • Geneva
    • Washington
    • Paris
    
    
19. Article 32 of the Indian Constitution deals with
    • Right to Property
    • Directive Principles of State Policy
    • Right to Constitutional Remedies
    • Freedom of Religion
    
    
20. Who wrote the book A Passage to England?
    • E.M. Foster
    • Nirad C. Chaudhuri
    • Kushwanth Singh
    • R.K. Narayan
    
    
21. Which one of the following is NOT a constituent of lung surfactant?
    • Dipalmitoyl lecithin
    • Sphingomyelin
    • Cholesterol
    • Phosphatidyl glycerol
    
    
22. Which one of the following molecular techniques is used to detect a specific RNA?
    • Southern blot technique
    • Northern blot technique
    • Western blot technique
    • In situ hybridization
    
    
23. Which one of the following features about genetic code is INCORRECT?
    • Non-degenerate
    • Non-ambiguous
    • Non-overlapping
    • Continuous
    
    
24. Which one of the following conditions results from defective alpha oxidation?
    • Methyl malonic aciduria
    • Glutaric aciduria
    • Refsum's disease
    • Propionic acidemia
    
    
25. Which one of the following amino acids is purely ketogenic?
    • Leucine
    • Isoleucine
    • Lysine
    • Phenyl alanine
    
    
26. All the following conditions show low serum AFP level EXCEPT
    • Down syndrome
    • Anencephaly
    • Trisomy 18
    • Turners syndrome
    
    
27. All the following statements regarding glutathione are true EXCEPT
    • It favours the absorption of neutral amino acids in the intestine
    • It inactivates insulin
    • It is an atypical tripeptide
    • It plays an important role in free radical scavenging
    
    
28. Which one of the following is NOT a post-transcriptional modification?
    • 5' capping
    • Poly-A tailing
    • Acetylation
    • Methylation
    
    
29. Select the FALSE statement regarding phosphofructokinase 1.
    • It is activated by AMP
    • Fructose 2,6 bisphosphate inhibits this enzyme
    • During starvation the synthesis of this enzyme is repressed
    • Fructose 6 phosphate activates this enzyme
    
    
30. All the following statements regarding pentose phosphate pathway is correct EXCEPT
    • Glucose-6-phosphate dehydrogenase is the rate limiting enzyme of the pathway
    • In RBCs it is the only source of NADPH for free radical scavenging
    • No ATP is produced in this pathway
    • Glucose-6-phosphate dehydrogenase is inhibited by insulin
    
    
31. Which one of the following statements about glycogen metabolism is INCORRECT?
    • Glucagon enhances glycogenolysis in muscle
    • Epinephrine enhances glycogenolysis in liver and muscle
    • Glycogenolysis in liver will lead to increase in blood glucose level
    • Pyridoxal phosphate is essential for glycogenolysis in muscle
    
    
32. Regarding pancreatic lipase the INCORRECT statement is
    • It is a glycoprotein
    • It's serum level is increased in renal insufficiency
    • It has a specificity of 80-100% in diagnosing acute pancreatitis
    • It's serum level increases within 8 to 12 hours and reaches a peak by 48 hours after an acute attack of pancreatitis
    
    
33. Which is the soluble storage form of iron in tissues?
    • Ferritin
    • Transferrin
    • Hemosiderin
    • Haptoglobin
    
    
34. Black liver jaundice is seen in
    • Dubin Johnson syndrome
    • Rotor syndrome
    • Glibert's disease
    • Crigler-Najjar syndrome
    
    
35. Select the neurotransmitter synthesized from tyrosine
    • GABA
    • Melatonin
    • Dopamine
    • Serotonin
    
    
36. Which of the following is used for staining DNA fragments in electrophoresis?
    • Coomasssie Brilliant Blue
    • Nitrotetrazolium Blue
    • Silver Nitrate
    • Ethidium Bromide
    
    
37. Which liver enzyme is best for detecting biliary obstruction?
    • Alanine amino transferase
    • Alkaline phosphatase
    • Nucleotide phosphatase
    • Gamma glutamyl transferase
    
    
38. Which of the following statement is NOT true regarding oncogenes?
    • Mutation in one of the two alleles is sufficient to produce oncogenic effects
    • Oncogenic effect is due to gain of function of a protein that stimulates cell growth and proliferation
    • Mutations in oncogenes may be present in somatic or germ cells
    • Usually do not show tissue preference with respect to the type of cancers in which they are found
    
    
39. All the following are multienzyme complexes EXCEPT
    • Pyruvate carboxylase
    • Alpha keto dehydrogenase
    • Acetyl Co A carboxylase
    • Pyruvate kinase
    
    
40. Which of the following is an example for non-competitive inhibition?
    • Allopurinol inhibits xanthine oxidase
    • Fluoride inhibits enolase
    • 5-fluorouracil inhibits thymidylate synthase
    • Lovastatin inhibits HMG Co A reductase
    
    
41. Which of the following is NOT a serine protease?
    • Trypsin
    • Thrombin
    • Carbonic anhydrase
    • Chymotrypsin
    
    
42. Which is the best marker of ventricular dysfunction?
    • CK-MB
    • Cardiac troponin I
    • Brain natriuretic peptide
    • Myoglobin
    
    
43. Select the glucose transporter that is insulin dependent.
    • GLUT 2
    • GLUT 4
    • GLUT 5
    • SGLT 1
    
    
44. Which of the following statement is FALSE regarding mitochondrial DNA?
    • Majority of the mitochondrial proteins are coded by mitochondrial DNA
    • Mitochondrial DNA have high mutation rate than nuclear DNA
    • Mitochondrial cytopathies show a maternal non-mendelian inheritance
    • Mitochondrial DNA shows heteroplasmy
    
    
45. Regarding p53 all the statements are true EXCEPT
    • Is a DNA binding transcription factor
    • Induces the genes that induce apoptosis
    • Is the least mutated genes in human cancers
    • Is a tumor suppressor gene
    
    
46. Regarding apoptosis, select the FALSE statement.
    • Cytochrome c is an inducer of apoptosis
    • bcl-2 is an apoptosis protecting gene
    • Caspase 3 is the initiator caspase of apoptosis
    • Ceramide is an important regulator of apoptosis
    
    
47. Which one of the following is a chain breaking anti-oxidant?
    • Catalase
    • Vitamin E
    • Glutathione peroxidase
    • Ethylenediaminetetraacetate
    
    
48. Select the enzyme that is NOT present in the liver.
    • HMG Co A lyase
    • HMG Co A synthase
    • Thiolase
    • Thiophorase
    
    
49. Correct Answer:- Option-D       Linoleic acid is considered to be a nutritionally essential fatty acid in humans BECAUSE
    • It is an omega 3 fatty acid
    • In humans double bond cannot be introduced at Δ⁶ position
    • In humans double bond cannot be introduced at Δ⁹ position
    • In humans double bond cannot be introduced at Δ¹² position
    
    
50. Regarding insulin which of the following statement is FALSE?
    • Inhibits hormone sensitive lipase
    • Inhibits acetyl Co A carboxylase
    • Activates glycerol phosphate acyl transferase
    • Activates pyruvate dehydrogenase
    
    
51. Which one of the following is NOT a cause of fatty liver?
    • Protein deficiency
    • Orotic acid deficiency
    • Pantothenic acid deficiency
    • Linoleic acid deficiency
    
    
52. Niemann-Pick disease is due to the deficiency of
    • Hexosaminidase A
    • Hexosaminidase A and B
    • Beta glucosidase
    • Sphingomyelinase
    
    
53. All the following statements are true regarding water EXCEPT
    • Water molecules form dipoles
    • The angle between two hydrogen atoms in water molecule is 105°
    • Has low dielectric constant
    • Is an excellent nucleophile
    
    
54. Which of the following can be a cause of Normal Anion Gap Metabolic Acidosis?
    • Organic aciduria
    • Salicylate poisoning
    • Acetazolamide therapy
    • Lactic acidosis
    
    
55. All the following statements regarding pKa are true EXCEPT
    • At pKa the ratio of salt to acid in a buffer is 2:1
    • At pKa the buffer has maximum buffering capacity
    • pKa of an acid is the pH at which the acid is half ionized
    • Weak acids have high pKa
    
    
56. Which one of the following test is used to detect CSF globulins?
    • Heller's test
    • Pandy's test
    • Oliver's test
    • Pettenkoffer's test
    
    
57. Of the following which hypotheses claims that there is an association between the predictor and outcome variables?
    • Alternative hypotheses
    • Null hypotheses
    • Statistical hypotheses
    • Composite hypotheses
    
    
58. If mean is 25 and standard deviation is 5, then coefficient of variation is
    • 5%
    • 20%
    • 25%
    • 75%
    
    
59. Which of the following is the best test based on the ROC curve?
    • Area under the curve is more than 0.9
    • Area under the curve is 0.5
    • Area under the curve is less than 0.1
    • Area under the curve is less than 0.01
    
    
60. Which one of the following statements is NOT TRUE regarding telomerase?
    • It's activity is increased in cancer
    • Loss of telomerase activity leads to aging
    • It is a ribozyme
    • It has reverse transcriptase activity
    
    
61. Which one of the following diseases results from defective nucleotide excision repair mechanism?
    • Xeroderma Pigmentosum
    • Hereditary Polyposis Colon Cancer
    • Fanconi's Anemia
    • Bloom's Syndrome
    
    
62. Which one of the following is NOT true regarding IgM?
    • Do not fix complement
    • Antigen receptor is on the surface of B cells
    • Do not cross the placenta
    • Involved in primary response
    
    
63. Which amino acid is relatively absent in alpha helices?
    • Glycine
    • Valine
    • Tryptophan
    • Arginine
    
    
64. Which one of the following diseases is due to defective collagen synthesis?
    • Leukocyte adhesion deficiency II
    • Ehlers-Danlos syndrome
    • Paroxysmal nocturnal hemoglobinuria
    • I-cell disease
    
    
65. Which of the following vitamins provide the cofactor for transketolase reaction?
    • Vitamin B₆
    • Niacin
    • Thiamine
    • Riboflavin
    
    
66. Which one of the following histone amino acid is typically acetylated?
    • Lysine
    • Arginine
    • Histidine
    • Leucine
    
    
67. Vitamin C is not synthesized in humans due to the deficiency of ____________.
    • L-Xylulose dehydrogenase
    • L-Gulonolactone oxidase
    • L-Gulonate oxidase
    • D-Glucuronate reductase
    
    
68. Correct Answer:- Option-B In the human body isoniazid is detoxified by _____________.
    • Acetylation
    • Methylation
    • Conjugation with sulphate
    • Conjugation with glycine
    
    
69. During protein synthesis which amino acid is incorporated first in eukaryotes?
    • N-formyl methionine
    • Methionine
    • Phenyl alanine
    • Glutamine
    
    
70. Tetany is found in all the following conditions EXCEPT
    • Hypoparathyroidism
    • Renal insufficiency
    • Vitamin D deficiency
    • Metabolic alkalosis
    
    
71. The reference interval for plasma osmolality is
    • 150 to 175 mOsmol/Kg
    • 300 to 325 mOsmol/L
    • 275 to 300 mOsmol/Kg
    • 350 to 375 mOsmol/L
    
    
72. Which one of the following is a marker of bone resorption?
    • Procollagen typeI N-terminal propeptide
    • C-telopeptide
    • Osteocalcin
    • Bone alkaline phosphatase
    
    
73. Specific dynamic action for protein is
    • 5%
    • 15%
    • 30%
    • 55%
    
    
74. Which of the following is NOT a constituent of human glycoproteins?
    • Glucose
    • Fucose
    • Xylose
    • Sucrose
    
    
75. In which of the following condition CSF glucose is normal?
    • Bacterial meningitis
    • Tuberculous meningitis
    • Viral meningitis
    • Brain tumor
    
    
76. Which one of the following statements is FALSE regarding nitric oxide?
    • Asparagine is the precursor of nitric oxide
    • Is a potent vasodilator
    • Depresses platelet function
    • Results in refractory hypotension in septicemia
    
    
77. Westgard multirule 4_1s is sensitive to which type of analytical error?
    • Systematic error
    • Imprecision error
    • Random error
    • Standardization error
    
    
78. Which is the optical technique that measures the emitted light by a species that has absorbed exciting radiation from an outside source?
    • Spectrophotometry
    • Reflectance photometry
    • Fluorometry
    • Nephelometry
    
    
79. In which condition is a decrease in serum albumin and an increase in alpha2-macroglobulin seen?
    • Cirrhosis
    • Inflammation
    • Multiple myeloma
    • Nephrotic syndrome
    
    
80. The most common biological recognition element used in a biosensor is
    • Antigen
    • Antibody
    • Enzyme
    • Hormone
    
    
81. Which of the following is the marker enzyme of microsomes?
    • Cathepsin
    • Galactosyl transferase
    • Catalase
    • Glucose-6-phosphatase
    
    
82. Hill equation explains
    • Bi-bi reaction of enzymes
    • Co-operative binding of enzymes
    • Ping-pong mechanism of enzymes
    • Suicidal inhibition of enzymes
    
    
83. Select the glycosaminoglycan which does not contain uronic acid.
    • Keratan sulfate
    • Chondroitin sulfate
    • Dermatan sulfate
    • Hyaluronic acid
    
    
84. Which of the following is NOT true regarding 2,3-BPG?
    • Stabilizes the T structure of hemoglobin
    • CO₂ increases the synthesis of 2,3-BPG
    • 2,3-BPG binds strongly to HbF than HbA
    • At high altitude the synthesis of 2,3-BPG is increased
    
    
85. Which of the following test is NOT used for the diagnosis of secondary adrenal insufficiency?
    • Dexamethasone suppression test
    • Cosyntropin test
    • Overnight metyrapone test
    • Insulin tolerance test
    
    
86. All the following hormones bind to cell surface receptors EXCEPT
    • Insulin
    • Substance P
    • Thyroid hormone
    • Glucagon
    
    
87. Which of the following hormone is NOT stored in the cells?
    • Parathormone
    • Aldosterone
    • Insulin
    • Adrenalin
    
    
88. Select the enzyme that is deficient in classical homocystinuria.
    • Adenosine homocysteinase
    • Homocysteine methyl transferase
    • Cystathionine beta synthase
    • Cystathionase
    
    
89. Which one of the following hormone is appetite suppressant?
    • Leptin
    • Ghrelin
    • Glucagon
    • Rennin
    
    
90. Which of the following is NOT a high energy compound?
    • Creatine phosphate
    • 1,3-bisphosphoglycerate
    • Glucose-6-phosphate
    • Carbamoyl phosphate
    
    
91. Which of the following is an excellent GFR marker?
    • Creatinine clearance
    • Cystatin C
    • Tamm Horsfall glycoprotein
    • Inulin clearance
    
    
92. Which one of the following enzyme catalyzes a substrate level phosphorylation reaction?
    • Phosphofructokinase
    • Glucokinase
    • Succinate thiokinase
    • Succinate dehydrogenase
    
    
93. Which one of the following is a selenium containing enzyme?
    • 5' deiodinase
    • Thyroperoxidase
    • Xanthine oxidase
    • Glutamate dehydrogenase
    
    
94. Select the enzyme that is deficient in Lesch-Nyhan syndrome
    • Phosphoribosyl amidotransferase
    • Hypoxanthine guanine phosphoribosyl transferase
    • Adenine phosphoribosyl transferase
    • Phosphoribosyl pyrophosphate synthase
    
    
95. Cataract in galactosemia is due to accumulation of
    • Dulcitol in lens
    • Sorbitol in lens
    • Mannitol in lens
    • Iduronic acid in lens
    
    
96. Which one of the following apoproteins is present in LDL?
    • Apo B-48
    • Apo B-100
    • Apo E
    • Apo C
    
    
97. Which one of the following statements is FALSE regarding tRNA?
    • Amino acid is attached to the 5' CCA sequence
    • DHU arm serves as the recognition site for the enzyme which adds the amino acid
    • Anticodon arm recognizes the triplet nucleotide codon present in m RNA
    • It contains the unusual amino acid hypoxanthine
    
    
98. All the following are autosomal recessive diseases EXCEPT
    • Albinism
    • Sickle cell anemia
    • Chondrodystrophy
    • Phenyl ketonuria
    
    
99. Which one of the following is NOT a substrate for gluconeogenesis?
    • Glycerol
    • Propionyl CoA
    • Even chain fatty acids
    • Lactate
    
    
100. All the following are features of kwashiorkor EXCEPT
     • Lethargic and apathetic
     • Presence of anorexia
     • Crazy pavement dermatitis
     • Serum albumin 2 to 3 g/dl