Assistant Professor Pharmacology 150/2018 Answer Key

Post: Assistant Professor Pharmacology
Department: Medical Education
Category Code: 150/18
Qualification: MD (Pharmacology)/ DNB (Pharmacology) + Three years Teaching Experience
Date of Test: 19-06-2019


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1. Domperidone is
   • 5HT₃ antagonist
   • 5HT₄ agonist
   • D2 antagonist
   • D2 agonist
   
   
2. Drug of choice in neurocysticercosis
   • Praziquantel
   • Albendazole
   • Ivermectin
   • Pyrantal pamoate
   
   
3. Stiripentol is an
   • Antipsychotic
   • Antiepileptic
   • Antiparkinsonian
   • Antidepressant
   
   
4. All are catecholamines except
   • Epinephrine
   • Norepinephrine
   • Dopamine
   • Phenylephrine
   
   
5. Fastest acting antimalarial drug
   • Chloroquine
   • Quinine
   • Mefloquine
   • Artesunate
   
   
6. The mechanism of action of sofosbuvir is
   • NS5B polymerase inhibitor
   • NS5A inhibitor
   • NS3 Protease inhibitor
   • Neuraminidase inhibitor
   
   
7. Drug which is not of microbial origin
   • Lovastatin
   • Ivermectin
   • Paclitaxel
   • Sirolimus
   
   
8. Essential drugs are
   • Life saving drugs
   • Drugs meeting the health needs of majority of population
   • Drugs that must be available in emergency departments
   • Drugs that are listed in pharmacopoeia of a nation
   
   
9. Loading dose of a drug primarily depends on
   • Volume of distribution
   • Clearance
   • Rate of administration
   • Plasma half-life
   
   
10. Selective estrogen receptor down regulator is
    • Clomiphene citrate
    • Toremifene
    • Letrozole
    • Fulvestrant
    
    
11. Ocular anti inflammatory agent among the following
    • Flurbiprofen
    • Indomethacin
    • Mefenamic acid
    • Piroxicam
    
    
12. NMDA receptor antagonist useful in Alzheimer's disease
    • Galantamine
    • Memantine
    • Donepezil
    • Co Dergocrine
    
    
13. Uses of ACE inhibitors are all except
    • Hypertension
    • Congestive cardiac failure
    • Myocardial infarction
    • Variant angina
    
    
14. Teriparatide can be used for the treatment of
    • Osteoporosis
    • Polycystic ovarian disease
    • Hyperparathyroidism
    • Hypocalcemia
    
    
15. Drug of choice in trigeminal neuralgia
    • Carbamazepine
    • Phenytoin
    • Lamotrigine
    • Sodium valproate
    
    
16. Conversion of T4 to T3 is inhibited by all EXCEPT
    • Propranolol
    • Propylthiouracil
    • Carbimazole
    • Amiodarone
    
    
17. Diuretic with anti remodelling action
    • Furosemide
    • Hydrochlorothiazide
    • Amiloride
    • Spironolactone
    
    
18. Mu receptor is responsible for all the following effects EXCEPT
    • Miosis
    • Bronchodilation
    • Euphoria
    • Hypothermia
    
    
19. Most cardiotoxic local anaesthetic is
    • Procaine
    • Prilocaine
    • Bupivacaine
    • Tetracaine
    
    
20. A normal distribution curve depends on
    • Mean and sample size
    • Mean and median
    • Range and sample size
    • Mean and standard deviation
    
    
21. SSRI useful in the treatment of premature ejaculation
    • Dapoxetine
    • Duloxetine
    • Venlafaxine
    • Sertraline
    
    
22. In a clinical trial, comparison of efficacy of a new drug with an existing drug is done in
    • Phase I
    • Phase II
    • Phase III
    • Phase IV
    
    
23. All of the following are short acting insulin analogs except
    • Insulin lispro
    • Insulin aspart
    • Insulin glargine
    • Insulin glulisine
    
    
24. Etravirine is
    • Nucleoside reverse transcriptase inhibitor
    • Non nucleoside reverse transcriptase inhibitor
    • Integrase inhibitor
    • Entry inhibitor
    
    
25. Physiological salt solution used for mammalian smooth muscle experiments
    • Tyrode solution
    • Frog ringer solution
    • De Jalon solution
    • Mc even solution
    
    
26. Drug most likely to cause malignant hyperthermia is
    • Propofol
    • Ketamine
    • Halothane
    • Thiopentone sodium
    
    
27. Squalene epoxidase inhibitor is
    • Terbinafine
    • Griseofulvin
    • Miconazole
    • Tolnaftate
    
    
28. Penicillin G is the drug of choice in
    • Rickettsial infection
    • Leptospirosis
    • Typhoid
    • Bacterial dysentery
    
    
29. cAMP is the second messenger for the following receptors except
    • Histamine H₂
    • Adrenergic β
    • Serotonin 5HT₂
    • Dopamin D₁
    
    
30. Glucocorticoid with the least mineralocorticoid activity is
    • Deflazacort
    • Prednisolone
    • Methylprednisolone
    • Hydrocortisone
    
    
31. Macrolide which achieves extensive tissue distribution is
    • Azithromycin
    • Roxithromycin
    • Clarithromycin
    • Erythromycin
    
    
32. Choose the wrong statement about metronidazole
    • Preferred drug in intestinal amoebiasis
    • Highly useful in anaerobic infections
    • Can product disulfiram like reaction with alcohol
    • Drug of choice for eradicating amoebic cysts from colon
    
    
33. Docetaxel acts on the following cell cycle phase
    • S phase
    • G1 phase
    • M phase
    • G2 phase
    
    
34. Gum hypertrophy is caused by all these drugs except
    • Phenytoin
    • Verapamil
    • Nifedipine
    • Cyclosporine
    
    
35. Drug of choice in digoxin induced ventricular arrhythmia
    • Propafenone
    • Lignocaine
    • Quindine
    • Procainamide
    
    
36. All are T type calcium channel blockers except
    • Flunarizine
    • Ethosuximide
    • Sodium valproate
    • Diltiazem
    
    
37. The physical half life of I¹³¹ is
    • 8 minutes
    • 8 hours
    • 8 days
    • 8 weeks
    
    
38. The neuromuscular blocking drug that can be used safety in patients with renal and hepatic dysfunction
    • Atracurium
    • Mivacurium
    • Pancuronium
    • Rocuronium
    
    
39. The 5-alpha reductase inhibitor effective in the treatment of male pattern baldness
    • Flutamide
    • Finasteride
    • Bicalutamide
    • Tadalafil
    
    
40. All of the following drugs are used in hypertensive emergencies except
    • sodium nitroprusside
    • Losartan
    • Labetalol
    • Esmolol
    
    
41. Inverse agonist of benzodiazepine receptor is
    • Flumazenil
    • Gabapentin
    • Beta carboline
    • Zopiclone
    
    
42. All are properties of digoxin except
    • Low steady margin
    • High volume of distribution
    • inhibits Na+K+ATPase
    • Metabolized in liver
    
    
43. Febuxostate is
    • Non purine inhibitor of xanthine oxidase
    • Used in acute gout
    • Uricosuric drug
    • Given intravenously
    
    
44. The drug with the least oral bioavailability among the following
    • Ampicillin
    • Gentamicin
    • Doxycycline
    • Ciprofloxacin
    
    
45. Prostaglandin analog used in the treatment of constipation predominant IBS
    • Lubiprostone
    • Alosetron
    • Prucalopride
    • Cisapride
    
    
46. A metal chelator which can be used in the treatment of a collagen vascular disease but may precipitate yet another collagen vascular disease
    • Penicillamine
    • Desferrioxamine
    • Dimercaprol
    • Calcium disodium edetate
    
    
47. Neurokinin receptor antagonist used in the treatment of chemotherapy induced vomitting
    • Dronabinol
    • Ondansetron
    • Aprepitant
    • Rimonabant
    
    
48. All are pharmacogenetically mediated reactions except
    • Adenosine deaminase deficiency
    • Succinylcholine apnoea
    • Coumarin insensitivity
    • G6PD deficiency
    
    
49. Which one of the following antimicrobial agent has got a ketolide structure
    • Linezolid
    • Streptogramins
    • Aztreonam
    • Telithromycin
    
    
50. Preferred drug for the treatment of pneumocystis Jiroveci Pneumonia
    • Erythromycin
    • Co-trimoxazole
    • Doxycycline
    • Clindamycin
    
    
51. Which of the following general anaesthetic has poor muscle relaxant action?
    • Ether
    • Nitrous oxide
    • Halothane
    • Ketamine
    
    
52. The dose limiting toxicity of doxorubicin is
    • Hepatic centrilobular necrosis
    • Congestive cardiac failure
    • Proximal tubular necrosis
    • Peripheral neuropathy
    
    
53. Characteristic feature of piperacillin is
    • Acid labile and penicillinase resistant
    • Acid resistant and penicillinase labile
    • Acid labile and penicillinase labile
    • Acid resistant and penicillinase resistant
    
    
54. Cytochrome P450 isoenzyme involved in the metabolism of most of the drugs is
    • CYP2E1
    • CYP2D6
    • CYP3A4
    • CYP2C19
    
    
55. Antipsychotic with prokinetic action
    • Levosulpiride
    • Amisulpride
    • Loxapine
    • Pimozide
    
    
56. Centrally acting skeletal muscle relaxant that acts via α2 adrenergic agonism
    • Tizanidine
    • Brimonidine
    • Baclofen
    • Chlormezanone
    
    
57. Which of the following is a phase 2 reaction?
    • Oxidation
    • Acetylation
    • Hydrolysis
    • Reduction
    
    
58. All of the following are anti seizure drugs useful for migraine prophylaxis except
    • Gabapentin
    • Topiramate
    • Vigabatrin
    • Sodium valproate
    
    
59. The following are mixed agonist antagonist except
    • Pentazocine
    • Nalbuphine
    • Fentanyl
    • Nalorphine
    
    
60. Chlorpromazine has all the following actions in addition to its anti dopaminergic effect except
    • Anticholinergic action
    • Antihistaminic action
    • Alpha adrenergic blocking action
    • Beta adrenergic blocking action
    
    
61. Valbenazine is
    • VMAT2 inhibitor
    • MAO-B inhibitor
    • COMT inhibitor
    • MAO-A inhibitor
    
    
62. Concerning streptogramin, which of the following statement is false?
    • Active against MRSA
    • Induce cytochrome P450 enzyme
    • Useful against vancomycin resistant enterococci
    • Excreted mainly through feces
    
    
63. The minimal alveolar concentration of an inhalational anaesthetic is a measure of its
    • Potency
    • Therapeutic index
    • Diffusibility
    • Efficacy
    
    
64. First line ACT under NVBDCP for chloroquine resistant falciparum malaria
    • Artesunate + sulfadoxine + pyrimethamine
    • Artemether + lumefantrine
    • Artesunate + mefloquine
    • Arterolane + piperaquine
    
    
65. About first order kinetics, true statement is
    • Fixed amount of the drug is eliminated
    • Clearance remains constant
    • Half-life increases with dose
    • Decreased clearance with increase in dose
    
    
66. Antagonism between adrenaline and histamine is
    • Physical antagonism
    • Physiological antagonism
    • Competitive equilibrium antagonism
    • Competitive non equilibrium antagonism
    
    
67. Which of the following is not associated with hydrochlorothiazide treatment
    • Hyponatremia
    • Hypokalemia
    • Hypocalcemia
    • Hyperuricemia
    
    
68. Aminoglycosides are not useful in the treatment of infections with
    • Pseudomonas
    • E Coli
    • Klebsiella
    • Clostridium difficile
    
    
69. Drug preferred in the treatment of swine flu
    • Abacavir
    • Oseltamivir
    • Acyclovir
    • Tenofovir
    
    
70. The name of ahlquist is associated with
    • Classification of cholinergic receptors
    • Classification of adrenergic receptors
    • Classification of histamine receptors
    • Classification of serotonin receptors
    
    
71. All of the following are disease modifying anti-rheumatoid drugs except
    • Etanercept
    • Anakinra
    • Infliximab
    • Cetuximab
    
    
72. Glycoprotein IIb/IIIa receptor antagonist is
    • Prasugrel
    • Ticlopidine
    • Tirofiban
    • Cangrelor
    
    
73. Preferred drug in the treatment of drug induced parkinsonism
    • Levodopa
    • Selegiline
    • Trihexyphenidyl
    • Tolcapone
    
    
74. Stimulation of which receptor will release renin?
    • Alpha 1
    • Alpha 2
    • Beta 1
    • Beta 2
    
    
75. Evolocumab is used in
    • Hyperlipidemia
    • Bronchial asthma
    • Migraine
    • Breast cancer
    
    
76. 5-HT1A partial agonist among the following
    • Ketanserin
    • Hydroxyzine
    • Cyproheptadine
    • Buspirone
    
    
77. All of the following can be used as local anaesthetics except
    • Dexmedetomidine
    • Centbucridine
    • Diphenhydramine
    • Benzyl alcohol
    
    
78. All of the following drugs are included under RNTCP for the treatment of XDR-TB except
    • Capreomycin
    • Levofloxacin
    • Clofazimine
    • Linezolid
    
    
79. Denosumab is used for the treatment of
    • Rheumatoid arthritis
    • Osteoarthritis
    • Osteoporosis
    • Systematic lupus erythematosus
    
    
80. Anthelmintic agent with immunomodulatory action
    • Albendazole
    • Pyrantel pamoate
    • Piperazine
    • Levamisole
    
    
81. The pass that connects Himachal Pradesh and Tibet is
    • Shipkila
    • Nathula
    • Banihal
    • Sojila
    
    
82. Name the chief Justice who issued verdict on the constitutionality of Adhar Card
    • T.S. Thakkur
    • Ranjan Gagoi
    • Dipak Misra
    • None of these
    
    
83. The founder of East India Association was
    • Surendra Nath Banerjee
    • Mahadev G. Ranade
    • Gopala Krishna Gokhale
    • Dadabai Naorji
    
    
84. Among the rivers given below which one flows to west?
    • Kaveri
    • Godavari
    • Mahanadi
    • Narmada
    
    
85. Dassault Aviation is an aircraft company from
    • Korea
    • Italy
    • America
    • France
    
    
86. In which annual session of Indian National Congress was, C. Sankaran Nair elected as the President
    • Bombay Session
    • Madras Session
    • Amaravathi Session
    • Nagpur Session
    
    
87. Mar Kuriakose Elias Chavara established a Sanskrit school at
    • Kollam
    • Mannanam
    • Kaladi
    • Aluva
    
    
88. The 44th G.7 summit was held at
    • Berlin
    • Tokyo
    • Melbaie
    • Paris
    
    
89. The constitutional reform that introduced dyarchy in provinces was
    • Minto Morly Reforms
    • Indian Act of 1935
    • Montagu Chelmsford Reform
    • Indian act of 1858
    
    
90. The revolt of Royal Indian Navy in 1946 begin in
    • Karachi
    • Vishakhapatanam
    • Bombay
    • Kolkata
    
    
91. Tata Iron and Steel Plant (TISCO) is situated at
    • Jharkand
    • West Bengal
    • Karnataka
    • Bihar
    
    
92. 'Prachina Malayalam' is the work of
    • Vaghbhadanandha
    • Vaikunda Swamikal
    • V.T. Bhattathirippad
    • Chattampi Swamikal
    
    
93. The venue of 2022 World Cup Foot Ball is
    • Russia
    • Mexico
    • Qatar
    • Canada
    
    
94. As per 2011 Census Report the district with highest sex ratio is
    • Malappuram
    • Alappuzha
    • Kannur
    • Thiruvananthapuram
    
    
95. 'Mangalavanam' bird sanctuary is in
    • Palakkad
    • Idukki
    • Kottayam
    • Ernakulam
    
    
96. The district with longest coastal area is
    • Kasargod
    • Kozhikode
    • Alappuzha
    • Kannur
    
    
97. Edamalayar Dam is constructed upon the river
    • Periyar
    • Pampa
    • Neyyar
    • Bharathapuzha
    
    
98. Mahatma Gandhi National Rural Employment Guarantee Programme (MNREGP) was introduced in
    • 2005
    • 2004
    • 2008
    • 2006
    
    
99. 'Ezhava Memorial' was submitted to
    • Sree Chithira Thirunal Balarama Varma
    • Gouri Parvathi Bhai
    • Sree Moolam Thirunal Ramavarma
    • Visakham Thirunal
    
    
100. 'Yachanayatra' was conducted by
     • A.K. Gopalan
     • T.K. Madhavan
     • V.T. Bhattathirippad
     • K. Kelappan